Liver glycogen

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Liver, Hepatocyte – Glycogen accumulation Liver, Hepatocyte – Glycogen depletion

Figure Legend: Figure 1 Glycogen accumulation–normal accumulation in hepatocytes in a female B6C3F1 mouse from a chronic study. Figure 2 Glycogen accumulation–normal mobilization of glycogen from centrilobular area in a male B6C3F1 mouse from a subchronic study. Figure 3 Glycogen accumulation–glycogen in all hepatocytes in a male B6C3F1 mouse from a subchronic study. Figure 4 Glycogen depletion...

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Liver Glycogen Phosphorylase Kinase

Liver glycogen phosphorylase kinase was assayed by measuring the radioactivity of [y-32P]ATP incorporated into rabbit skeletal muscle phosphorylase b. Using this assay two forms of phosphorylase kinase, Kinase I and Kinase II, were pirified about 70and 130-fold, respectively, from rabbit liver cytosol by DEAE-Sephadex A50 column chromatography, ammonium sulfate fractionation, gel filtration on ...

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Liver glycogen in diabetes mellitus.

The present consensus of opinion regarding the amount of liver glycogen in diabetes mellitus is well exemplified by Korenberg (1943), "Although opinions differ as to the exact mechanism responsible for the syndrome of diabetes mellitus, unanimity exists with regard to the fact that in that condition the hepatic glycogen is decreased. . ." and Mirsky (1942), "The most important cause of diabetic...

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Rabbit Liver Glycogen Synthase Kinases

A rabbit liver protein kinase (PCO.,), able to phosphorylate glycogen synthase and phosvitin, has been extensively purified. The enzyme had apparent M, = 170,000-190,000 as judged by gel filtration and was associated with two major polypeptide species, a (Mr = 43,000) and lp (Mr = 25,000). Two other polypeptides, Mr = 38,000 and M, = 35,000, were also detected. Treatment with trypsin led to an...

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Regulation of rat liver glycogen synthetase. Carboxylic acid activation of liver glycogen synthetase.

Rat liver glycogen synthetase is strongly stimulated by cellular carboxylic acids which are intermediates of glycolysis and the tricarboxylic acid cycle. Activation of glycogen synthetase by the carboxylic acids may coordinate hepatic glycogen deposition with the functional status of the tricarboxylic acid cycle. At physiological concentrations of the carboxylic acids, the I form is preferentia...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1936

ISSN: 0306-3283

DOI: 10.1042/bj0301612